Syracuse University's Center for Digital Literacy has collaborated with a number of internal and external partners for its projects and activities, including:

American Association of School Librarians
Apple Computers
Binghamton City School District
Bronx Zoo
By Kids For Kids
Creative Media Solutions, Oriental, NC
Data Momentum, Ithaca, NY
Information Institute of Syracuse (IIS), School of Information Studies
Ithaca Museum of the Earth, Ithaca, NY
New York City Department of Education
ProLiteracy Worldwide
Rochester City School District
Strong National Museum of Play, Rochester, NY
Syracuse City School District
Syracuse University Libraries
Training Systems Institute (TSI), Department of Instructional Design, Development & Evaluation, School of Education
Valiant Technologies (UK)
Vecna
Worldwide Workshop Foundation